AON Vision

European Cornmjss ' aon

Brian O ’ Rourke , Sonia Cortassa and Miguel A . Aon

[PDF] [Full Text] [Abstract] , December 1, 2006; 20 (14): 2556-2558. FASEB J G. R. Budas, A. Sukhodub, D. R. Alessi and A. Jovanovic 3'phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium [PDF] [Full Text] [Abstract] , June 1, 2007; 67 (11): 5561-5568. Cancer Res. S. S. N. Kolar, R. Barhoumi, J. R. Lupton and R. S. Chapkin Mitochondrial Ca2+ Accumu...

AON-Mediated Exon Skipping for Duchenne Muscular Dystrophy

Vision in Hyphema

Persistent Dystrophin Protein Restoration 90 Days after a Course of Intraperitoneally Administered Naked 2′OMePS AON and ZM2 NP-AON Complexes in mdx Mice

In Duchenne muscular dystrophy, the exon-skipping approach has obtained proof of concept in animal models, myogenic cell cultures, and following local and systemic administration in Duchenne patients. Indeed, we have previously demonstrated that low doses (7.5 mg/Kg/week) of 2'-O-methyl-phosphorothioate antisense oligoribonucleotides (AONs) adsorbed onto ZM2 nanoparticles provoke widespread dys...